Khalid al-Azm was a Syrian politician and five-time interim Prime Minister, as well as Acting President from 4 April to 16 September 1941. He was a member of one of the most prominent political families in Syria, al-Azm, and the son of an Ottoman minister of religious affairs.

Al-Azm family is a prominent Damascene family. Their political influence in Ottoman Syria began in the 18th century when members of the family administered Maarrat al-Nu'man and Hama. A scion of the family, Ismail Pasha al-Azm, was appointed wāli of Damascus Eyalet in 1725. Between 1725 and 1783, members of the family, including As'ad Pasha al-Azm, held power in Damascus for 47 years, in addition to periodical appointments in Sidon Eyalet, Tripoli Eyalet, Hama, Aleppo Eyalet, and Egypt Eyalet. The family's influence declined in the 19th century, failing to establish a true dynasty.