The Kissimmee River is a river in south-central Florida, United States that forms the north part of the Everglades wetlands area. The river begins at East Lake Tohopekaliga south of Orlando, flowing south through Lake Kissimmee into the large, shallow Lake Okeechobee. Hurricane-related floods in 1947 prompted channelization of the meandering lower stretch, completed by 1970. The straightened course reduced wetland habitat and worsened pollution. In response, efforts since the 1990s have partially restored the river's original state and revitalized the ecosystem, as part of the broader restoration of the Everglades.

The Everglades is a natural region of flooded grasslands in the southern portion of the U.S. state of Florida, comprising the southern half of a large drainage basin within the Neotropical realm. The system begins near Orlando with the Kissimmee River, which discharges into the vast but shallow Lake Okeechobee. Water leaving the lake in the wet season forms a slow-moving river 60 miles (97 km) wide and over 100 miles (160 km) long, flowing southward across a limestone shelf to Florida Bay at the southern end of the state. The Everglades experiences a wide range of weather patterns, from frequent flooding in the wet season to drought in the dry season. Throughout the 20th century, the Everglades suffered significant loss of habitat and environmental degradation.