The LGM-118 Peacekeeper, originally known as the MX for "Missile, Experimental", was a MIRV-capable intercontinental ballistic missile (ICBM) produced and deployed by the United States from 1985 to 2005. The missile could carry up to twelve Mark 21 reentry vehicles, each armed with a 300-kiloton W87 warhead. Initial plans called for building and deploying 100 MX ICBMs, but budgetary concerns limited the final procurement; only 50 entered service. Disarmament treaties signed after the Peacekeeper's development led to its withdrawal from service in 2005.

A multiple independently targetable reentry vehicle (MIRV) is an exoatmospheric ballistic missile payload containing several warheads, each capable of being aimed to hit a different target. The concept is almost invariably associated with intercontinental ballistic missiles carrying thermonuclear warheads, even if not strictly being limited to them. An intermediate case is the multiple reentry vehicle (MRV) missile which carries several warheads which are dispersed but not individually aimed. All nuclear-weapon states except Pakistan and North Korea are currently confirmed to have deployed MIRV missile systems. Israel is suspected to possess or be in the process of developing MIRVs.