The Titan II was an intercontinental ballistic missile (ICBM) developed by the Glenn L. Martin Company from the earlier Titan I missile. Titan II was originally designed and used as an ICBM, but was later adapted as a medium-lift space launch vehicle to carry payloads to Earth orbit for the United States Air Force (USAF), National Aeronautics and Space Administration (NASA) and National Oceanic and Atmospheric Administration (NOAA). Those payloads included the USAF Defense Meteorological Satellite Program (DMSP), NOAA weather satellites, and NASA's Gemini crewed space capsules. The modified Titan II SLVs were launched from Vandenberg Air Force Base, California, up until 2003.

An intercontinental ballistic missile (ICBM) is a ballistic missile with a range greater than 5,500 kilometres (3,400 mi), primarily designed for nuclear weapons delivery. Conventional, chemical, and biological weapons can also be delivered with varying effectiveness, but have never been deployed on ICBMs. Most modern designs support multiple independently targetable reentry vehicle (MIRVs), allowing a single missile to carry several warheads, each of which can strike a different target. The United States, Russia, China, France, India, the United Kingdom, Israel, and North Korea are the only countries known to have operational ICBMs.