The La Crosse–Onalaska Metropolitan Statistical Area, as defined by the United States Census Bureau, is an area consisting of La Crosse County, Wisconsin and Houston County, Minnesota, anchored by the cities of La Crosse and Onalaska. The area is part of what is commonly referred to as the Coulee Region or 7 Rivers Region. As of the 2020 census, the MSA had a population of 139,627, and in 2022 estimates placed the total population at 139,094.

La Crosse County is a county located in the U.S. state of Wisconsin. At the 2020 census, the population was 120,784. Its county seat is La Crosse. La Crosse County is included in the La Crosse-Onalaska, WI-MN Metropolitan Statistical Area with a population of 139,627 and is the most populous county on Wisconsin's western border.