La Crosse County is a county located in the U.S. state of Wisconsin. At the 2020 census, the population was 120,784. Its county seat is La Crosse. La Crosse County is included in the La Crosse-Onalaska, WI-MN Metropolitan Statistical Area with a population of 139,627 and is the most populous county on Wisconsin's western border.

La Crosse is a city in and the county seat of La Crosse County, Wisconsin, United States. Positioned alongside the Mississippi River, La Crosse is the largest city on Wisconsin's western border. La Crosse's population was 52,680 as of the 2020 census. The city forms the core of the La Crosse–Onalaska metropolitan area, which includes all of La Crosse County and Houston County, Minnesota, with a population of 139,627.