La Crosse station is an Amtrak intercity train station in La Crosse, Wisconsin, served the daily Empire Builder. The station was built in 1926–27 by the Chicago, Milwaukee, St. Paul, and Pacific Railroad, replacing an older station that burned in 1916. The station was listed on the National Register of Historic Places as the Chicago, Milwaukee and St. Paul Railway Depot and was renovated in 2001.

La Crosse is a city in and the county seat of La Crosse County, Wisconsin, United States. Positioned alongside the Mississippi River, La Crosse is the largest city on Wisconsin's western border. La Crosse's population was 52,680 as of the 2020 census. The city forms the core of the La Crosse–Onalaska metropolitan area, which includes all of La Crosse County and Houston County, Minnesota, with a population of 139,627.