La Défense station is a station of the Transilien suburban rail lines, RER commuter rail network, Paris Métro, as well as a stop of the Île-de-France tram network. In the future, Paris Metro Line 15 of Grand Paris Express will pass through here, making it a huge railway hub. It is underneath the Grande Arche building in La Défense, the business district just west of Paris. The station is the western terminus of Métro Line 1 and connects the RER A line to the Métro Line 1 station La Défense–Grande Arche since 1992, the Line 2 tramway since 1994 and SNCF (Transilien) train station. It is also attached to a major shopping centre. There are over 25 million entries and exits each year. A temporary special SNCF service began in April 1959 to serve the newly-built Centre of New Industries and Technologies (CNIT); the RER entered service on 19 January 1970.

Île-de-France tramway Line 2 is part of the modern tram network of the Île-de-France region of France. It connects the commune of Bezons in the north to the Porte de Versailles Métro station in Paris in the south, serving Hauts-de-Seine and its La Défense business district.