La Grande River is a river in northwestern Quebec, Canada, rising in the highlands of the north-central part of the province and flowing roughly 900 km (560 mi) west to its drainage at James Bay. It is the second-longest river in the province, surpassed only by the Saint Lawrence River.

James Bay is a large body of water located on the southern end of Hudson Bay in Canada. It borders the provinces of Quebec and Ontario, and is politically part of Nunavut. Its largest island is Akimiski Island.