La Reina is a commune of Chile located in Santiago Province, Santiago Metropolitan Region, created in 1963 from an eastern portion of the Ñuñoa commune. It belongs to the Northeastern zone of Santiago de Chile.

Santiago Province is one of the six provinces of the Santiago Metropolitan Region (RM) of central Chile. It encompasses the majority of the population of that region, including 31 of the 36 communities of Greater Santiago. The province spans 2,030.30 km (1,262 mi).