The Lackawanna River is a 42-mile-long (68 km) tributary of the Susquehanna River in Northeastern Pennsylvania. It flows through a region of the northern Pocono Mountains that was once a center of anthracite coal mining in the United States. It starts in north Wayne County, Pennsylvania and ends in east Luzerne County, Pennsylvania in Duryea, Pennsylvania. The lower reaches of the river flow through the urban areas of Scranton, which grew around its banks in the 19th century as an industrial center. Its name comes from a Lenape word meaning "stream that forks".

The Susquehanna River is a major river located in the Mid-Atlantic region of the United States, overlapping between the lower Northeast. At 444 miles (715 km) long, it is the longest river on the East Coast of the United States. By watershed area, it is the 16th-largest river in the United States, and also the longest river in the early 21st-century continental United States without commercial boat traffic.