Lady's Island is a predominantly residential Sea Island located in Beaufort County, South Carolina. Small portions of the island are within the City of Beaufort, while the majority of the island remains unincorporated. The South Carolina Highway 802, also known locally as Sams Point Road, serves as the principal highway for Lady's Island and provides the only access to Coosaw Island.

Beaufort County is a county in the U.S. state of South Carolina. As of the 2020 census, its population was 187,117. Its county seat is Beaufort and its largest community is Hilton Head Island.