The Laguna Madre is a long, shallow, hypersaline lagoon along the western coast of the Gulf of Mexico in Nueces, Kenedy, Kleberg, Willacy and Cameron Counties in Texas, United States. It is one of seven major estuaries along the Gulf Coast of Texas. The roughly 20-mile (32 km) long Saltillo Flats land bridge divides it into Upper and Lower lagoons joined by the Intracoastal Waterway, which has been dredged through the lagoon. Cumulatively, Laguna Madre is approximately 130 miles (210 km) long, the length of Padre Island in the US. The main extensions include Baffin Bay in Upper Laguna Madre, Red Fish Bay just below the Saltillo Flats, and South Bay near the Mexican border. As a natural ecological unit, the Laguna Madre of the United States is the northern half of the ecosystem as a whole, which extends into Tamaulipas, Mexico approximately 144 miles (232 km) south of the US border, to the vicinity of the Rio Soto La Marina and the town of La Pesca, extending approximately 275 miles (443 km) through USA and Mexico in total.

The U.S. state of Texas has a series of estuaries along its coast on the Gulf of Mexico, most of them bounded by the Texas barrier islands. Estuaries are coastal bodies of water in which freshwater from rivers mixes with saltwater from the sea. Twenty-one drainage basins terminate along the Texas coastline, forming a chain of seven major and five minor estuaries: listed from southwest to northeast, these are the Rio Grande Estuary, Laguna Madre, the Nueces Estuary, the Mission–Aransas Estuary, the Guadalupe Estuary, the Colorado–Lavaca Estuary, East Matagorda Bay, the San Bernard River and Cedar Lakes Estuary, the Brazos River Estuary, Christmas Bay, the Trinity–San Jacinto Estuary, and the Sabine–Neches Estuary. Each estuary is named for its one or two chief contributing rivers, excepting Laguna Madre, East Matagorda Bay, and Christmas Bay, which have no major river sources. The estuaries are also sometimes referred to by the names of their respective primary or central water bodies, though each also includes smaller secondary bays, inlets, or other marginal water bodies.