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Lake Neuchâtel

Lake Neuchâtel is a lake in Romandy, in the French-speaking part of Switzerland. The lake lies in the canton of Neuchâtel, but is shared by the cantons of Vaud and Bern. With a surface of 218.3 km2, Lake Neuchâtel is the largest lake located in Switzerland and the 59th largest lake in Europe. It is 8.2 km at its widest. Its surface is 429 metres above sea level, the maximum depth is 152 metres; the total water volume is 14.0 km3. The lake's drainage area is 2,670 km2 and its culminating point is Le Chasseron at 1,607 metres; the lake is fed by the rivers L'Orbe, L'Arnon, L'Areuse, Le Seyon, La Menthue, as well as by the Canal de la Broye. The Thielle Canal drains the lake into Lake Biel and is part of regulation system for the lakes and the rivers of the Seeland region. Lake Neuchâtel was the home of the now extinct species of deepwater trout Salvelinus neocomensis. From Yverdon to La Tène: Yverdon-les-Bains Grandson Bonvillars Onnens Corcelles-près-Concise Concise Vaumarcus Sauges Saint-Aubin Gorgier, Chez-Le-Bart Bevaix Cortaillod Areuse Colombier Auvernier Serrières Neuchâtel Hauterive St-Blaise Marin-Epagnier From Yverdon to Gampelen: Cheseaux Yvonand Cheyres Châbles Font Estavayer-le-Lac Forel Chevroux Pré de Riva Portalban Chabrey Champmartin Cudrefin La Sauge Lindehof, Witzwil Tannenhof "Neuchâtel, Lake of".

Encyclopædia Britannica. 19. 1911. P. 424–425. Waterlevels at the Harbour of Neuchâtel from the Swiss Federal Office for the Environment

Li coronemenz Looïs

Li coronemenz Looïs is an anonymous twelfth-century Old French chanson de geste. It is sometimes attributed to Bertrand de Bar-sur-Aube and dated 1137; the first modern critical edition of the text was published in 1888 by Ernest Langlois under the title Le Couronnement de Louis. The chanson is, about the coronation of Louis the Pious, son of Charlemagne; the story begins with the aging emperor preparing to abdicate the throne to his fifteen-year-old son. Louis is hesitant in the face of the enormous responsibilities; when the emperor dies, to the spontaneous ringing of bells, Arnéïs d'Orléans assumes the reins of government until the young prince has come of age. Guillaume soon embarks on a pilgrimage to Rome with the young Louis and there they find the city besieged by Saracens. Guillaume challenges a Saracen champion to single combat and decisively defeats him, becoming a champion of the Pope and the saviour of Rome in the process, he has lost, the tip of his nose, from the Saracen's sword, is thenceforth known by the sobriquet Guillaume au court nez: Guillaume of the short nose.

This early chanson is historical in character. Its description of Charlemagne is gleaned from the entry for the year 813 in the Vita Hludowici; as it was composed during the reign of Louis VII of France, for most of his life without a male heir, the politics behind the story's strong emphasis on the hereditary nature of kingship is partial to the Capetian. Le Couronnement de Louis, ed. Ernest Langlois

Clinical trial registration

Clinical trial registration is the practice of documenting clinical trials before they are performed in a clinical trials registry so as to combat publication bias and selective reporting. Registration of clinical trials is required in some countries and is being standardized; some top medical journals will only publish the results of trials. A clinical trials registry is a platform. ClinicalTrials.gov, run by the United States National Library of Medicine was the first online registry for clinical trials, remains the largest and most used. In addition to combating bias, clinical trial registries serve to increase transparency and access to clinical trials for the public. Clinical trials registries are searchable. Trials are registered by the pharmaceutical, biotech or medical device company or by the hospital or foundation, sponsoring the study, or by another organization, such as a contract research organization, running the study. There has been a push from governments and international organizations since 2005, to make clinical trial information more available and to standardize registries and processes of registering.

The World Health Organization is working toward "achieving consensus on both the minimal and the optimal operating standards for trial registration". For many years and others have worried about reporting biases such that negative or null results from initiated clinical trials may be less to be published than positive results, thus skewing the literature and our understanding of how well interventions work; this worry has written about for over 50 years. One of the proposals to address this potential bias was a comprehensive register of initiated clinical trials that would inform the public which trials had been started. Ethical issues were those that seemed to interest the public most, as trialists benefited from those who enrolled in trials, but were not required to “give back,” telling the public what they had learned; those who were concerned by the double standard were systematic reviewers, those who summarize what is known from clinical trials. If the literature is skewed the results of a systematic review are likely to be skewed favoring the test intervention when in fact the accumulated data do not show this, if all data were made public.

ClinicalTrials.gov was developed as a result of breast cancer consumer lobbying, which led to authorizing language in the FDA Modernization Act of 1997, but the law provided neither funding nor a mechanism of enforcement. In addition, the law required that ClinicalTrials.gov only include trials of serious and life-threatening diseases. Two events occurred in 2004 that increased public awareness of the problems of reporting bias. First, the then-New York State Attorney General Eliot Spitzer sued GlaxoSmithKline because they had failed to reveal results from trials showing that certain antidepressants might be harmful. Shortly thereafter, the International Committee of Medical Journal Editors announced that their journals would not publish reports of trials unless they had been registered; the ICMJE action was the most important motivator for trial registration, as investigators wanted to reserve the possibility that they could publish their results in prestigious journals, should they want to.

In 2007, the Food and Drug Administration Amendments Act of 2007 clarified the requirements for registration and set penalties for non-compliance (Public Law 110-85. The Food and Drug Administration Amendments Act of 2007; the International Committee of Medical Journal Editors decided that from July 1, 2005 no trials will be considered for publication unless they are included on a clinical trials registry. The World Health Organization has begun the push for clinical trial registration with the initiation of the International Clinical Trials Registry Platform. There has been action from the pharmaceutical industry, which released plans to make clinical trial data more transparent and publicly available. Released in October 2008, the revised Declaration of Helsinki, states that "Every clinical trial must be registered in a publicly accessible database before recruitment of the first subject."The World Health Organization maintains an international registry portal at http://apps.who.int/trialsearch/.

WHO states that the international registry's mission is "to ensure that a complete view of research is accessible to all those involved in health care decision making. This will improve research transparency and will strengthen the validity and value of the scientific evidence base."Since 2007, the International Committee of Medical Journal Editors ICMJE accepts all primary registries in the WHO network in addition to clinicaltrials.gov. Various studies have measured the extent to which various trials are in compliance with the reporting standards of their registry. Worldwide, there is growing number of registries. A 2013 study identified the following top five registries

Mahindra Rakshak

The Mahindra Rakshak is an armored military light utility vehicle made by Mahindra Defense Systems, based on the chassis of the Mahindra Commander jeep. The Rakshak was designed to be used in anti-terrorism operations; the Rakshak jeep was launched in 2000 in collaboration with Plasan. The vehicle was first manufactured under Mahindra Specialties; the Rakshak was placed under scrutiny in 2008 when the government alleged that the engine used was suitable for 1,600 kg and below and that the vehicle was 2,660 kg, making it unsafe to use in areas where militants have a strong influence. In response to this allegation MDS CEO Brig. Khutab Hai stated that the company had supplied the army with Rakshaks outfitted with new engines with a higher power and increased torque in order improve the vehicle's ability to climb in hilly terrain, it was suggested that the contract was made under a short time with the Comptroller and Auditor General investigating if any rules were violated. In 2009, the Mahindra Special Military Vehicles in Prithla, Faridabad was established with a capacity to manufacture a minimum of 500 vehicles per year.

In 2012, the Mumbai Police requested a tender for bulletproof, run flat types and tubeless rims to replace those are in use. Jammu & Kashmir Police reported that in 2014, 100 Rakshaks in service had not received replacement engines following flood damage due to lack of supply; the Rakshak is made with its armored plating made by Plasan Sasa, obtained via technology transfer. It is meant to be a cost-effective vehicle for security forces that cannot afford high-end armored vehicles, it is designed to withstand 7.62mm rounds from 10 meters with the flooring armored to withstand grenade explosions. It uses a manual transmission for a four-wheel drive and has the option of installing an air conditioner system. During live fire tests, 41 bullets were fired at the Rakshak and hurled at least one grenade underneath it; the Rakshak Plus was publicly displayed at the DEFEXPO 2012 convention. It weighs 600 kg and has a PTZ surveillance camera installed, which has a 360 degree view with zooming capacity of 500 meters.

It has a 2.2-litre m-Hawk turbocharged and intercooled diesel engine with a roof gun mount and back protection plates, five firing ports, fire suppression material in the fuel tank, air conditioning and power steering. It has level 3 armor. Ghana: Unknown number of Rakshaks reported to be exported in 2008. Guyana: Two Rakshaks used by the Guyana Police Force under the Berbice Police Division. India: 200 Rakshaks used by the Indian Army with 800 ordered in 2009, the former purchased in 2005 under a contract for Rs 35.76 crore. Used by the Mumbai Police. Used by police forces in Jammu and Kashmir, Andhra Pradesh, Bihar Manipur and Chhattisgarh. Nepal: Unknown number of Rakshaks reported to be exported in 2008. Sri Lanka: Unknown number of Rakshaks reported to be exported in 2008. Official Website

Hugh Boyle (golfer)

Hugh F. Boyle was an Irish professional golfer best known for his achievements in the mid-1960s. Boyle was born in County Louth, Ireland. In 1966 he was the winner of both the Yomiuri International and the Daks Tournament, in 1965 he was second in the Senior Service Tournament while in 1967 he gained a second place in the Schweppes Open He finished in eighth place at the 1967 Open Championship, behind the champion, Roberto DeVicenzo, second placed, Jack Nicklaus, at the Royal Liverpool Golf Club, his final round of 68 won him the Tooting Bec Cup. He won the Irish PGA Championship in 1967. Boyle represented Ireland in the 1967 World Cup in Mexico City, his continued success won him a place on the 1967 Ryder Cup team, where he played twice against Arnold Palmer in the pairs and Gay Brewer in the singles. Boyle held the professional course record at the Royal Norwich Golf Club with a score of 66. In 1983, Boyle became a head professional at the Royal Wimbledon Club, a position he retained for over twenty years.

1966 Yomiuri International, Daks Tournament 1967 Irish PGA Championship, Blaxnit Tournament Note: Boyle only played in The Open Championship. CUT = missed the half-way cut "T" indicates a tie for a place Ryder Cup: 1967 World Cup: 1967 R. T. V. International Trophy: 1967 Double Diamond International: 1971, 1972

Runcinated 6-simplexes

In six-dimensional geometry, a runcinated 6-simplex is a convex uniform 6-polytope constructed as a runcination of the regular 6-simplex. There are 8 unique runcinations of the 6-simplex with permutations of truncations, cantellations. Small prismated heptapeton The vertices of the runcinated 6-simplex can be most positioned in 7-space as permutations of; this construction is based on facets of the runcinated 7-orthoplex. Small biprismated tetradecapeton The vertices of the biruncinted 6-simplex can be most positioned in 7-space as permutations of; this construction is based on facets of the biruncinated 7-orthoplex. Note: Symmetry doubled for Ak graphs with k due to symmetrically-ringed Coxeter-Dynkin diagram. Prismatotruncated heptapeton The vertices of the runcitruncated 6-simplex can be most positioned in 7-space as permutations of; this construction is based on facets of the runcitruncated 7-orthoplex. Biprismatorhombated heptapeton The vertices of the biruncitruncated 6-simplex can be most positioned in 7-space as permutations of.

This construction is based on facets of the biruncitruncated 7-orthoplex. Prismatorhombated heptapeton The vertices of the runcicantellated 6-simplex can be most positioned in 7-space as permutations of; this construction is based on facets of the runcicantellated 7-orthoplex. Runcicantitruncated heptapeton Great prismated heptapeton The vertices of the runcicantitruncated 6-simplex can be most positioned in 7-space as permutations of; this construction is based on facets of the runcicantitruncated 7-orthoplex. Biruncicantitruncated heptapeton Great biprismated tetradecapeton The vertices of the biruncicantittruncated 6-simplex can be most positioned in 7-space as permutations of; this construction is based on facets of the biruncicantitruncated 7-orthoplex. Note: Symmetry doubled for Ak graphs with k due to symmetrically-ringed Coxeter-Dynkin diagram; the truncated 6-simplex is one of 35 uniform 6-polytopes based on the Coxeter group, all shown here in A6 Coxeter plane orthographic projections.

H. S. M. Coxeter: H. S. M. Coxeter, Regular Polytopes, 3rd Edition, Dover New York, 1973 Kaleidoscopes: Selected Writings of H. S. M. Coxeter, edited by F. Arthur Sherk, Peter McMullen, Anthony C. Thompson, Asia Ivic Weiss, Wiley-Interscience Publication, 1995, ISBN 978-0-471-01003-6 H. S. M. Coxeter and Semi Regular Polytopes I, H. S. M. Coxeter and Semi-Regular Polytopes II, H. S. M. Coxeter and Semi-Regular Polytopes III, Norman Johnson Uniform Polytopes, Manuscript N. W. Johnson: The Theory of Uniform Polytopes and Honeycombs, Ph. D. Klitzing, Richard. "6D uniform polytopes". X3o3o3x3o3o - spil, o3x3o3o3x3o - sibpof, x3x3o3x3o3o - patal, o3x3x3o3x3o - bapril, x3o3x3x3o3o - pril, x3x3x3x3o3o - gapil, o3x3x3x3x3o - gibpof Polytopes of Various Dimensions Multi-dimensional Glossary