Lane Seminary, sometimes called Cincinnati Lane Seminary, and later renamed Lane Theological Seminary, was a Presbyterian theological college that operated from 1829 to 1932 in Walnut Hills, Ohio, today a neighborhood in Cincinnati. Its campus was bounded by today's Gilbert, Yale, Park, and Chapel Streets.

Theodore Dwight Weld was one of the architects of the American abolitionist movement during its formative years from 1830 to 1844, playing a role as writer, editor, speaker, and organizer. He is best known for his co-authorship of the authoritative compendium American Slavery as It Is: Testimony of a Thousand Witnesses, published in 1839. Harriet Beecher Stowe partly based Uncle Tom’s Cabin on Weld's text; the latter is regarded as second only to the former in its influence on the antislavery movement. Weld remained dedicated to the abolitionist movement until slavery was ended by the Thirteenth Amendment to the United States Constitution in 1865.