Laredo–Nuevo Laredo is one of six transborder agglomerations along the U.S.-Mexican border. The city of Laredo is situated in the U.S. state of Texas on the northern bank of the Rio Grande and Nuevo Laredo is located in the Mexican State of Tamaulipas in the southern bank of the river. This area is also known as the Two Laredos or the Laredo Borderplex. The area is made up of one county in the U.S and three municipalities in Mexico. Two urban areas, three cities, and 12 towns make the Laredo–Nuevo Laredo Metropolitan area. The two sides of the Borderplex are connected by four International Bridges and an International Railway Bridge. The Laredo–Nuevo Laredo Metropolitan area has a total of 636,516 inhabitants according to the INEGI Census of 2010 and the United States Census estimate of 2010. According to World Gazetteer this urban agglomeration ranked 157th largest in North and South America in 2010 with an estimated population of 675,481. This area ranks 66th in the United States and 23rd in Mexico.

Laredo is a city in the U.S. state of Texas and seat of Webb County, on the north bank of the Rio Grande in South Texas, across from Nuevo Laredo, Tamaulipas, Mexico. Founded in 1755, Laredo grew from a village to the capital of the short-lived Republic of the Rio Grande to the largest inland port on the Mexican border. Laredo's economy is primarily based on international trade with Mexico, and as a major hub for three areas of transportation: land, rail, and air cargo. The city is on the southern end of I-35, which connects manufacturers in northern Mexico through Interstate 35 as a major route for trade throughout the U.S. It has four international bridges and one railway bridge.