The House of Laskaris, Latinized as Lascaris, was a Byzantine Greek noble family which rose to prominence during the late Byzantine period. The members of the family formed the ruling dynasty of the Empire of Nicaea, a Byzantine rump state that existed from the 1204 sack of Constantinople by the Fourth Crusade until the restoration of the Empire under the Palaeologan dynasty in 1261.

John III Doukas Vatatzes, Latinized as Ducas Vatatzes, was Emperor of Nicaea from 1221 to 1254. He was succeeded by his son, known as Theodore II Laskaris.