Late Night with Conan O'Brien is an American late-night talk show hosted by Conan O'Brien. NBC aired 2,725 episodes from September 13, 1993, to February 20, 2009. The show featured varied comedic material, celebrity interviews, and musical and comedy performances. Late Night aired weeknights at 12:37 am Eastern/11:37 pm Central and 12:37 am Mountain in the United States. From 1993 until 2000, Andy Richter served as O'Brien's sidekick; following his departure, O'Brien was the show's sole featured performer. The show's house musical act was The Max Weinberg 7 and led by E Street Band drummer Max Weinberg.

Conan Christopher O'Brien is an American television host, comedian, writer, and producer. He is best known for having hosted late-night talk shows, beginning with Late Night with Conan O'Brien (1993–2009) and The Tonight Show with Conan O'Brien (2009–2010) on the NBC television network, and Conan (2010–2021) on the cable channel TBS. Before his hosting career, O'Brien was a writer for the NBC sketch comedy series Saturday Night Live from 1988 to 1991, and the Fox animated sitcom The Simpsons from 1991 to 1993. He has also been host of the podcast series Conan O'Brien Needs a Friend since 2018 and starred in the 2024 travel show Conan O'Brien Must Go on Max.