Leakesville is a town in and the county seat of Greene County, Mississippi, United States. It is located along the Chickasawhay River in Greene County, Mississippi, United States. It is served by the junction of Mississippi routes 57 and 63. As of the 2010 census, the rural town population was 898, down from 1,026 at the 2000 census.

Greene County is a county located on the southeast border of the U.S. state of Mississippi. As of the 2020 census, the population was 13,530. Its county seat is Leakesville. Established in 1811, the county was named for General Nathanael Greene of the American Revolutionary War.