Lenox Avenue – also named Malcolm X Boulevard; both names are officially recognized – is the primary north–south route through Harlem in the upper portion of the New York City borough of Manhattan. This two-way street runs from Farmers' Gate at Central Park North to 147th Street. Its traffic is figuratively described as "Harlem's heartbeat" by Langston Hughes in his poem Juke Box Love Song. The IRT Lenox Avenue Line runs under the entire length of the street, serving the New York City Subway's 2 and ​3 trains.

Harlem is a neighborhood in Upper Manhattan, New York City. It is bounded roughly by the Hudson River on the west; the Harlem River and 155th Street on the north; Fifth Avenue on the east; and Central Park North on the south. The greater Harlem area encompasses several other neighborhoods and extends west and north to 155th Street, east to the East River, and south to Martin Luther King Jr. Boulevard, Central Park, and East 96th Street.