Lipid signaling
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Lipid signaling, broadly defined, refers to any biological cell signaling event involving a lipid messenger that binds a protein target, such as a receptor, kinase or phosphatase, which in turn mediat
Cartoon of second messenger systems. Figure adapted From Barbraham Institute Mike Berridge. https://web.archive.org/web/20090323190124/http://www.babraham.ac.uk/emeritus/berridge.html (accessed Jan. 21, 2008).
Second messenger system
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Second messengers are intracellular signaling molecules released by the target cell in response to exposure to extracellular signaling molecules—the first messengers. Second messengers trigger physiol
Lipid signaling
…of ceramidase by growth-inducing proteins such as platelet-derived growth factor and insulin-like growth factor, is consistent with its function as a second messenger. It was found that immediate hydrolysis of only 3 to 10% of newly generated ceramide may double the levels of Sph. Treatment of HL60 cells (a type of…
General Schematic of Second Messenger Mechanism