"Little Sister" is a rock and roll song written by Doc Pomus and Mort Shuman. It was originally released as a single in 1961 by American singer Elvis Presley, who enjoyed a No. 5 hit with it on the Billboard Hot 100. The single also reached No. 1 in the UK Singles Chart. Lead guitar was played by Hank Garland and the rhythm guitar was played by Scotty Moore with backing vocals by the Jordanaires featuring the distinctive bass voice of Ray Walker.

Jerome Solon Felder, known professionally as Doc Pomus, was an American blues singer and songwriter. He is best known as the co-writer of many rock and roll hits. Pomus was inducted into the Rock and Roll Hall of Fame as a non-performer in 1992, the Songwriters Hall of Fame (1992), and the Blues Hall of Fame (2012).