The Lockyer Creek is a creek in South East Queensland, Australia. A tributary of the Brisbane River, the creek is a major drainage system in the Lockyer Valley. Rising on the eastern slopes of the Great Dividing Range, the creek flows generally north-easterly for more than 100 kilometres (62 mi) before it reaches its confluence with the Brisbane River north-northeast of Lowood, and downstream from the Wivenhoe Dam. The creek is named after Edmund Lockyer.

The Brisbane River is the longest river in South East Queensland, Australia, and flows through the city of Brisbane, before emptying into Moreton Bay on the Coral Sea. John Oxley, the first European to explore the river, named it after the Governor of New South Wales, Sir Thomas Brisbane in 1823. The penal colony of Moreton Bay later adopted the same name, eventually becoming the present city of Brisbane. The river is a tidal estuary and the water is brackish from its mouth through the majority of the Brisbane metropolitan area westward to the Mount Crosby Weir. The river is wide and navigable throughout the Brisbane metropolitan area.