Locust Point is a peninsular neighborhood in Baltimore, Maryland. Located in South Baltimore, the neighborhood is entirely surrounded by the Locust Point Industrial Area; the traditional boundaries are Lawrence street to the west and the Patapsco River to the north, south, and east. It once served as a center of Baltimore's Polish-American, Irish-American and Italian-American communities; in more recent years Locust Point has seen gradual gentrification with the rehabilitation of Tide Point and Silo Point. The neighborhood is also noted as being the home of Fort McHenry and the western end of its namesake tunnel that carries eight lanes of Interstate 95 under the river.

Baltimore is the most populous city in the U.S. state of Maryland. With a population of 585,708 at the 2020 census, it is the 30th-most populous city in the United States. Baltimore was designated an independent city by the Constitution of Maryland in 1851, and is currently the most populous independent city in the nation. As of the 2020 census, the population of the Baltimore metropolitan area was 2,838,327, the 20th-largest metropolitan area in the country. When combined with the larger Washington metropolitan area, the Washington–Baltimore combined statistical area (CSA) has a 2020 U.S. census population of 9,973,383, the third-largest in the country.