Los Lagos Region is one of Chile's 16 regions, which are first order administrative divisions, and comprises four provinces: Chiloé, Llanquihue, Osorno and Palena. The region contains the country's second largest island, Chiloé, and the second largest lake, Llanquihue. Its capital is Puerto Montt; other important cities include Osorno, Castro, Ancud, and Puerto Varas. The mainland portion of Los Lagos Region south of Reloncaví Sound is considered part of Patagonia.

Chiloé Island also known as Greater Island of Chiloé, is the largest island of the Chiloé Archipelago off the west coast of Chile, in the Pacific Ocean. The island is located in southern Chile, in the Los Lagos Region.