The Los Ríos Region is one of Chile's 16 regions, the country's first-order administrative divisions. Its capital is Valdivia. It began to operate as a region on October 2, 2007, having been created by subdividing the Los Lagos Region in southern Chile. It consists of two provinces: Valdivia and the newly created Ranco Province, which was formerly part of Valdivia Province.

Valdivia is a city and commune in southern Chile, administered by the Municipality of Valdivia. The city is named after its founder, Pedro de Valdivia, and is located at the confluence of the Calle-Calle, Valdivia, and Cau-Cau Rivers, approximately 15 km (9 mi) east of the coastal towns of Corral and Niebla. Since October 2007, Valdivia has been the capital of Los Ríos Region and is also the capital of Valdivia Province. The national census of 2017 recorded the commune of Valdivia as having 166,080 inhabitants (Valdivianos), of whom 150,048 were living in the city. The main economic activities of Valdivia include tourism, wood pulp manufacturing, forestry, metallurgy, and beer production. The city is also the home of the Austral University of Chile, founded in 1954 and the Centro de Estudios Científicos.