"Lovesick Blues" is a Tin Pan Alley song, composed by Cliff Friend, with lyrics by Irving Mills. It first appeared in the 1922 musical "Oh, Ernest", and was recorded that year by Elsie Clark and Jack Shea. Emmett Miller recorded it in 1925 and 1928, followed by country music singer Rex Griffin in 1939. The recordings by Griffin and Miller inspired Hank Williams to perform the song during his first appearances on the Louisiana Hayride radio show in 1948. Receiving an enthusiastic reception from the audience, Williams decided to record his own version despite initial push back from his producer Fred Rose and his band.

Hiram King "Hank" Williams was an American singer-songwriter. He is regarded as one of the most significant and influential American singers and songwriters of the 20th century. Williams recorded 55 singles that reached the top 10 of the Billboard Country & Western Best Sellers chart, five of which were released posthumously, and 12 of which reached No.1.