Lu'ay al-Atassi was a Syrian military officer who served as the President of Syria from 9 March to 27 July 1963.

Atassi is the name of a prominent family in Homs, Syria, of a noble and ancient lineage, dating back to the 15th century AD. More recently, members of the family led the national movement against the French mandate. The power and prestige of the family reached an apex at the formation of the modern Republic of Syria in 1936, when its second head of state, Hashim al-Atassi was elected president. Two out of the seven members of the constitutional assembly who drafted the first constitution of Syria in 1919 were prominent Atassis: Wasfi al-Atassi and Hashim al-Atassi. Two more scions, Lu'ay al-Atassi and Nureddin al-Atassi, were in turn installed as heads of state in the 1960s. Family members included magistrates, governors, ambassadors, heads of political parties, military officers and other public officials throughout Ottoman and modern times.