Lucrezia Borgia is a melodramatic opera in a prologue and two acts by Gaetano Donizetti. Felice Romani wrote the Italian libretto after the play Lucrezia Borgia by Victor Hugo, in its turn after the legend of Lucrezia Borgia. Lucrezia Borgia was first performed on 26 December 1833 at La Scala, Milan.

Domenico Gaetano Maria Donizetti was an Italian composer, best known for his almost 70 operas. Along with Gioachino Rossini and Vincenzo Bellini, he was a leading composer of the bel canto opera style during the first half of the nineteenth century and a probable influence on other composers such as Giuseppe Verdi. Donizetti was born in Bergamo in Lombardy. At an early age he was taken up by Simon Mayr who enrolled him with a full scholarship in a school which he had set up. There he received detailed musical training. Mayr was instrumental in obtaining a place for Donizetti at the Bologna Academy, where, at the age of 19, he wrote his first one-act opera, the comedy Il Pigmalione, which may never have been performed during his lifetime.