Mühlheim am Main is a town of roughly 28,500 inhabitants on the Main’s left bank in the Offenbach district in the Regierungsbezirk of Darmstadt in Hesse, Germany. Its municipal area measures 20.67 km2.

The Main is the longest tributary of the Rhine. It rises as the White Main in the Fichtel Mountains of northeastern Bavaria and flows west through central Germany for 525 kilometres (326 mi) to meet the Rhine below Rüsselsheim, Hesse. The cities of Mainz and Wiesbaden are close to the confluence.