M-52 is a north–south state trunkline highway in the US state of Michigan. The southern terminus is on the Ohio border, where it continues as State Route 109. The highway passes through communities like Adrian, where it intersects US Highway 223 (US 223), Chelsea and Webberville along its 127.3-mile-long (204.9 km) course. It crosses some major rivers, including the River Raisin and the Shiawassee. The section of the highway between M-50 and Manchester was built as a limited-access highway. M-52's northern terminus is at M-46, nine miles (14 km) west of Saginaw.

M-46 is an east–west state trunkline highway in the US state of Michigan between Muskegon and Port Sanilac, terminating near Lake Michigan and Lake Huron on each end. Except for the north–south segment that corresponds with the US Highway 131 (US 131) freeway between Cedar Springs and Howard City, M-46 is practically a due east–west surface highway. The road runs through rural sections of the Lower Peninsula connecting several freeways including US 31, US 131, US 127 and Interstate 75 (I-75).