M-52 is a north–south state trunkline highway in the US state of Michigan. The southern terminus is on the Ohio border, where it continues as State Route 109. The highway passes through communities like Adrian, where it intersects US Highway 223 (US 223), Chelsea and Webberville along its 127.3-mile-long (204.9 km) course. It crosses some major rivers, including the River Raisin and the Shiawassee. The section of the highway between M-50 and Manchester was built as a limited-access highway. M-52's northern terminus is at M-46, nine miles (14 km) west of Saginaw.

State Route 109 (SR 109) is a 52.9-mile (85.1 km) state route that runs between Ottawa and the Michigan state line in the US state of Ohio. It crosses a major river, the Maumee, east of Napoleon. Most of the route is a rural two-lane highway and passes through both farmland and residential properties.