Project MKUltra was an illegal human experiments program designed and undertaken by the U.S. Central Intelligence Agency (CIA) to develop procedures and identify drugs that could be used during interrogations to weaken people and force confessions through brainwashing and psychological torture. It began in 1953 and was halted in 1973. MKUltra used numerous methods to manipulate its subjects' mental states and brain functions, such as the covert administration of high doses of psychoactive drugs and other chemicals without the subjects' consent, electroshocks, hypnosis, sensory deprivation, isolation, verbal and sexual abuse, and other forms of torture.

Brainwashing, also known as mind control, menticide, coercive persuasion, thought control, thought reform, and forced re-education, is the concept that the human mind can be altered or controlled by certain psychological techniques. Brainwashing is said to reduce its subject's ability to think critically or independently, to allow the introduction of new, unwanted thoughts and ideas into their minds, as well as to change their attitudes, values, and beliefs.