Madisonville is a home rule-class city in and the county seat of Hopkins County, Kentucky, United States, located along Interstate 69 in the state's Western Coal Fields region. The population was 19,591 at the 2010 census. Madisonville is a commercial center of the region and is home to Madisonville Community College.

U.S. Route 41, also U.S. Highway 41 (US 41), is a major north–south United States Numbered Highway that runs from Miami, Florida, to the Upper Peninsula of Michigan. Until 1949, the part in southern Florida, from Naples to Miami, was US 94. The highway's southern terminus is in the Brickell neighborhood of Downtown Miami at an intersection with Brickell Avenue (US 1), and its northern terminus is east of Copper Harbor, Michigan, at a modest cul-de-sac near Fort Wilkins Historic State Park at the tip of the Keweenaw Peninsula. US 41 closely parallels Interstate 75 (I-75) from Naples, Florida, all the way through Georgia to Chattanooga, Tennessee.