Madisonville is a home rule-class city in and the county seat of Hopkins County, Kentucky, United States, located along Interstate 69 in the state's Western Coal Fields region. The population was 19,591 at the 2010 census. Madisonville is a commercial center of the region and is home to Madisonville Community College.

Hopkins County is a county located in the western part of the U.S. state of Kentucky. As of the 2020 census, the population was 45,423. Its county seat is Madisonville. Hopkins County was created December 9, 1806, from Henderson County. It was named for General Samuel Hopkins, an officer in both the American Revolutionary War and War of 1812, and later a Kentucky legislator and U.S. Congressman.