The Main Avenue Bridge is a cantilever truss bridge in Cleveland, Ohio carrying Ohio State Route 2/Cleveland Memorial Shoreway over the Cuyahoga River. The bridge, completed in 1939, is 8,000 feet (2,400 m) in length, and was the longest elevated structure in Ohio until the 2007 completion of the Veterans' Glass City Skyway in Toledo. It was named for Harold H. Burton, 45th mayor of Cleveland, in late January 1986. The bridge replaced an 1869 bridge at the same site, and was built in conjunction with construction of the Cleveland Memorial Shoreway.

State Route 2, formerly known as Inter-county Highway 2 until 1921 and State Highway 2 in 1922, is an east–west highway crossing most of northern Ohio. Its western terminus is at the Indiana state line near Hicksville where the route becomes Indiana State Road 37 which continues to Fort Wayne, Indiana. The eastern terminus of the route is in Painesville Township in Lake County at U.S. Route 20 (US 20).