Manhattan Melodrama is a 1934 American pre-Code crime drama film, produced by MGM, directed by W. S. Van Dyke, and starring Clark Gable, William Powell, and Myrna Loy. The movie also provided one of Mickey Rooney's earliest film roles. The film is based on a story by Arthur Caesar, who won the Academy Award for Best Original Story. It was also the first of Myrna Loy and William Powell's fourteen screen pairings.

William Horatio Powell was an American actor, known primarily for his film career. Under contract with Metro-Goldwyn-Mayer, he was paired with Myrna Loy in 14 films, including the Thin Man series based on the Nick and Nora Charles characters created by Dashiell Hammett. Powell was nominated for the Academy Award for Best Actor three times: for The Thin Man (1934), My Man Godfrey (1936), and Life with Father (1947).