Manhattan Melodrama is a 1934 American pre-Code crime drama film, produced by MGM, directed by W. S. Van Dyke, and starring Clark Gable, William Powell, and Myrna Loy. The movie also provided one of Mickey Rooney's earliest film roles. The film is based on a story by Arthur Caesar, who won the Academy Award for Best Original Story. It was also the first of Myrna Loy and William Powell's fourteen screen pairings.

Woodbridge Strong Van Dyke II was an American film director who made several successful early sound films, including Tarzan the Ape Man in 1932, The Thin Man in 1934, San Francisco in 1936, and six popular musicals with Nelson Eddy and Jeanette MacDonald. He received two Academy Award nominations for Best Director for The Thin Man and San Francisco, and directed four actors to Oscar nominations: William Powell, Spencer Tracy, Norma Shearer, and Robert Morley. Known as a reliable craftsman who made his films on schedule and under budget, he earned the name "One Take Woody" for his quick and efficient style of filming.