A Mars sample-return (MSR) mission is a proposed mission to collect rock and dust samples on Mars and return them to Earth. Such a mission would allow more extensive analysis than that allowed by onboard sensors.

A sample-return mission is a spacecraft mission to collect and return samples from an extraterrestrial location to Earth for analysis. Sample-return missions may bring back merely atoms and molecules or a deposit of complex compounds such as loose material and rocks. These samples may be obtained in a number of ways, such as soil and rock excavation or a collector array used for capturing particles of solar wind or cometary debris. Nonetheless, concerns have been raised that the return of such samples to planet Earth may endanger Earth itself.