The George C. Marshall Space Flight Center (MSFC), located in Redstone Arsenal, Alabama, is the U.S. government's civilian rocketry and spacecraft propulsion research center. As the largest NASA center, MSFC's first mission was developing the Saturn launch vehicles for the Apollo program. Marshall has been the lead center for the Space Shuttle main propulsion and external tank; payloads and related crew training; International Space Station (ISS) design and assembly; computers, networks, and information management; and the Space Launch System. Located on the Redstone Arsenal near Huntsville, MSFC is named in honor of General of the Army George C. Marshall.

Redstone Arsenal is a United States Army base adjacent to Huntsville, Alabama in the Wheeler National Wildlife Refuge. A census-designated place in Madison County, Alabama, United States, it is part of the Huntsville-Decatur Combined Statistical Area. The Arsenal is a host to over 75 tenant agencies including the Department of Defense (DoD), Department of Justice (DOJ), the Federal Bureau of Investigation (FBI), and NASA's largest field center, the Marshall Space Flight Center.