Mary Jane "MJ" Watson is a character appearing in American comic books published by Marvel Comics. The character was created by Stan Lee and Steve Ditko, making her first appearance in The Amazing Spider-Man #25, and subsequently designed by John Romita Sr. in #42. Since then, she has gone on to become Spider-Man's main love interest and later his wife. Mary Jane is his most famous and prominent love interest due to their long history, and one of the most iconic in all of comics.

The Amazing Spider-Man is an ongoing American superhero comic book series featuring the Marvel Comics superhero Spider-Man as its title character and main protagonist. Being in the mainstream continuity of the franchise, it was the character's first title, launching seven months after his introduction in the final issue of Amazing Fantasy. The series began publication with a March 1963 cover date and has been published nearly continuously to date over six volumes with only one significant interruption. Issues of the title currently feature an issue number within its sixth volume, as well as a "legacy" number reflecting the issue's overall number across all Amazing Spider-Man volumes. The title reached 900 issues in 2022.