Route 133 is a 40.87-mile-long (65.77 km) east–west Massachusetts state route that runs from Route 38 and Route 110 in Lowell to Route 127 in Gloucester.

Route 38 is a state highway in the U.S. state of Massachusetts, traveling 26.5 miles (42.6 km) from Route 28 in Somerville north via Lowell to the New Hampshire state line in Dracut, where it continues as New Hampshire Route 38 in Pelham, New Hampshire. Although its southern terminus is at Route 28, some signage indicates that Route 38 continues south towards Sullivan Square in Boston.