Route 16 is a 59.8646-mile-long (96.3427 km) east–west state highway in Massachusetts. It begins in the west at an intersection with Route 12 and Route 193 in Webster, just north of the Connecticut state border. It runs in a generally southwest-northeast routing through a number of Boston's suburbs and runs to the west and then north of the city before ending in Revere at an intersection with Route 1A and Route 60.

Revere is a city in Suffolk County, Massachusetts, located approximately 5 miles (8.0 km) from downtown Boston. Founded as North Chelsea in 1846, it was renamed in 1871 after Revolutionary War patriot Paul Revere. In 1914, the Town of Revere voted to become a city and was incorporated as a city with the inauguration of its first mayor on January 4, 1915. At the 2020 census, the city had a population of 62,186 inhabitants.