Route 16 is a 59.8646-mile-long (96.3427 km) east–west state highway in Massachusetts. It begins in the west at an intersection with Route 12 and Route 193 in Webster, just north of the Connecticut state border. It runs in a generally southwest-northeast routing through a number of Boston's suburbs and runs to the west and then north of the city before ending in Revere at an intersection with Route 1A and Route 60.

Interstate 395 (I-395) is an auxiliary Interstate Highway in the U.S. states of Connecticut and Massachusetts; it is maintained by the Connecticut Department of Transportation (CTDOT) and the Massachusetts Department of Transportation (MassDOT). Spanning nearly 67 miles (108 km) on a south–north axis, it is the only spur route of I-95 in Connecticut. The 36-mile (58 km) section between its splits from I-95 in East Lyme and SR 695 in Plainfield is a component highway of the Connecticut Turnpike. Within that state, the highway is named the American Ex-Prisoner of War Memorial Highway from Plainfield to Thompson.