Route 63 is a 24.048-mile-long (38.702 km) state highway in Massachusetts, United States, running from Route 116 in Amherst north to the New Hampshire state line in Northfield, where it continues as New Hampshire Route 63. Along the way, it intersects several major highways, including Route 2 in Erving and Route 10 in Northfield.

Route 116 is a 68.26-mile-long (109.85 km) north–south state highway in Massachusetts. The route runs from Route 20A in Springfield through mill towns, college towns and rural towns, crossing the Connecticut River three times before finally ending at Route 8 in Adams.