In mass spectrometry, matrix-assisted laser desorption/ionization is an ionization technique that uses a laser energy-absorbing matrix to create ions from large molecules with minimal fragmentation. I
MALDI TOF mass spectrometer
Sample target for a MALDI mass spectrometer
In the lucky survivor model, positive ions can be formed from highly charged clusters produced during break-up of the matrix- and analyte-containing solid.
Soft laser desorption
Videos
Soft laser desorption is laser desorption of large molecules that results in ionization without fragmentation. "Soft" in the context of ion formation means forming ions without breaking chemical bonds
A commercial NALDI target