McGehee mə-GHEE is a city in Desha County, Arkansas, United States. The population was 4,219 at the 2010 census.

U.S. Route 165 is a north–south United States highway spur of U.S. Highway 65. It currently runs for 412 miles (663 km) from U.S. Route 90 in Iowa, Louisiana north to U.S. Highway 70 in North Little Rock, Arkansas. The route passes through the states of Arkansas and Louisiana. It passes through the cities of Monroe and Alexandria in Louisiana. A segment of US 165 serves as a routing of the Great River Road within Arkansas.