McGrath is a city and village on the Kuskokwim River in Alaska, United States. The population was 301 at the 2020 census. Despite its small population, the village is an important transportation and economic hub for the area.

The Kuskokwim River or Kusko River is a river, 702 miles (1,130 km) long, in Southwest Alaska in the United States. It is the ninth largest river in the United States by average discharge volume at its mouth and seventeenth largest by basin drainage area. The Kuskokwim River is the longest river system contained entirely within a single U.S. state.