The Mediterranean and Middle East Theatre was a major theatre of operations during the Second World War. The vast size of the Mediterranean and Middle East theatre saw interconnected naval, land, and air campaigns fought for control of the Mediterranean, North Africa, the Horn of Africa, the Middle East and Southern Europe. The fighting lasted from 10 June 1940, when Italy entered the war on the side of Germany, until 2 May 1945 when all Axis forces in Italy surrendered. However, fighting would continue in Greece – where British troops had been dispatched to aid the Greek government – during the early stages of the Greek Civil War.

The Mediterranean Sea is a sea connected to the Atlantic Ocean, surrounded by the Mediterranean Basin and almost completely enclosed by land: on the north by Southern Europe and Anatolia, on the south by North Africa, and on the east by the Levant in West Asia. The Mediterranean has played a central role in the history of Western civilization. Geological evidence indicates that around 5.9 million years ago the Mediterranean was cut off from the Atlantic and was partly or completely desiccated over a period of some 600,000 years during the Messinian salinity crisis before being refilled by the Zanclean flood about 5.3 million years ago.