Melksham railway station serves the town of Melksham in Wiltshire, England. It is 100 miles 13 chains measured from London Paddington, on the TransWilts Line between Chippenham and Trowbridge that was originally part of the Wilts, Somerset and Weymouth Railway, absorbed in 1850 by the Great Western Railway.

Melksham is a town and civil parish on the River Avon in Wiltshire, England, about 4.5 miles (7 km) northeast of Trowbridge and 6 miles (10 km) south of Chippenham. At the 2021 census, the parish had a population of 18,113.