The Wessex Main Line is the railway line from Bristol Temple Meads to Southampton Central. Diverging from this route is the Heart of Wessex Line from Westbury to Weymouth. The Wessex Main Line intersects the Reading to Taunton Line at Westbury and the West of England Main Line at Salisbury.

Bristol Temple Meads is the oldest and largest railway station in Bristol, England. It is located 118 miles 31 chains away from London Paddington. It is an important transport hub for public transport in the city; there are bus services to many parts of the city and surrounding districts, with a ferry to the city centre. Bristol's other major station, Bristol Parkway, is a more recent station on the northern outskirts of the conurbation. It is the busiest station in South West England.