Memphis Central Station, referred to as Grand Central Station prior to 1944, is a passenger terminal in Memphis, Tennessee. Located along Main Street and G.E. Patterson Boulevard in Downtown Memphis, it currently a service stop for Amtrak's City of New Orleans route, arriving in late evening northbound and in the morning southbound. It is also served by the MATA Trolley system. The building was opened in 1914, and is located within the city's South Main Arts District. It is also an contributing property to the South Main Street Historic District of the National Register of Historic Places, as are the National Civil Rights Museum and other historic properties within the district boundaries.

The South Main Street Historic District in Memphis, Tennessee, is located south of the city's central business district encompassing over 100 mostly commercial buildings spread across 11 blocks. The area was constructed between 1900 and 1930 in a wide range of early-twentieth-century architectural styles including Beaux Arts, Georgian Revival, Art Deco and Chicago Commercial. The district was added to the National Register of Historic Places in 1982 as an area of Memphis representing the impact of the railroad on the city during the a period of railroad-led prosperity that ended with the Great Depression. The district includes the Lorraine Motel, constructed in 1925, where Martin Luther King Jr. was assassinated in 1968. The South Main Arts District is a smaller area within the historic district. The district is also a City of Memphis local historic district or Historic Overlay District.