Memphis Central Station, referred to as Grand Central Station prior to 1944, is a passenger terminal in Memphis, Tennessee. Located along Main Street and G.E. Patterson Boulevard in Downtown Memphis, it currently a service stop for Amtrak's City of New Orleans route, arriving in late evening northbound and in the morning southbound. It is also served by the MATA Trolley system. The building was opened in 1914, and is located within the city's South Main Arts District. It is also an contributing property to the South Main Street Historic District of the National Register of Historic Places, as are the National Civil Rights Museum and other historic properties within the district boundaries.

Downtown Memphis, Tennessee is the central business district of Memphis, Tennessee and is located along the Mississippi River between Interstate 40 to the north, Interstate 55 to the south and I-240 to the east, where it abuts Midtown Memphis.