Mephisto is a fictional character appearing in American comic books published by Marvel Comics. The character first appeared in Silver Surfer #3, and was created by Stan Lee and John Buscema and based on Mephistopheles: a demon character from the Faust legend, who has sometimes been referred to as Mephisto. Introduced as a recurring adversary of the Silver Surfer and Ghost Rider, Mephisto has also endured as one of Spider-Man's most prominent adversaries, being responsible for Norman and Harry Osborn's respective transformations into the Green Goblin and Kindred; and for the superhero's loss of his marriage to Mary Jane Watson, considering their future daughter Spider-Girl his archenemy. Mephisto has often come into conflict with Doctor Strange, Doctor Doom, Scarlet Witch and other heroes of the Marvel Universe, being responsible both for the creation of the Cosmic Ghost Rider and the descents of Phil Coulson and Otto Octavius into villainy.

Mephistopheles, also known as Mephisto, is a demon featured in German folklore. He originally appeared in literature as the demon in the Faust legend and has since become a stock character appearing in other works of arts and popular culture.